Imataka K, Sakamoto H, Okamoto E, Ieki K, Fujii J
Institute for Adult Diseases, Asahi Life Foundation, Tokyo.
J Cardiol Suppl. 1992;28:47-51; discussion 52-3.
To evaluate cardiac injury induced by injection of 3 kinds of catecholamine, 219 male rabbits were examined. Eighty-five to 100 percent of the animals having high doses of adrenaline and noradrenaline showed ventricular premature contraction, and 65 to 75 percent of them showed mitral complex injury; whereas, these effects were identified in none or only in 10 percent of the animals with isoproterenol injection. The cardiac injury was similar to that of vagal stimulation, which was reported previously. These results indicate that ventricular premature contractions are important for developing the adrenaline- and noradrenaline-induced mitral complex injury.
为评估注射3种儿茶酚胺所诱导的心脏损伤，对219只雄性兔子进行了检查。给予高剂量肾上腺素和去甲肾上腺素的动物中，85%至100%出现室性早搏，其中65%至75%出现二尖瓣复合伤；而注射异丙肾上腺素的动物中，无此效应或仅有10%的动物出现此效应。心脏损伤与先前报道的迷走神经刺激所致损伤相似。这些结果表明，室性早搏对于肾上腺素和去甲肾上腺素诱导的二尖瓣复合伤的发生很重要。
