Fisher R I, Young R C
Cancer. 1977 Feb;39(2 Suppl):967-72. doi: 10.1002/1097-0142(197702)39:2+<967::aid-cncr2820390736>3.0.co;2-g.
The age adjusted death rate for ovarian cancer has remained unchanged for the past 20 years. Recent data obtained by staging ovarian cancer patients with lymphangiography and peritoneoscopy demonstrated that many patients with apparently localized disease actually have occult dissemination within the abdomen. These new staging techniques plus the determination of the histologic grade of anaplasia may permit a more precise determination of a patient's prognosis and therefore better design of therapeutic stategy. Radiotherapeutic techniques are being adapted to attempt to treat some areas of occult disease. Numerous single chemotherapeutic agents are capable of producing objective tumor responses. Preliminary data suggest that combination chemotherapy can increase the objective response rate above that seen with single agents. Longer follow-up is necessary to determine whether combination chemotherapy can prolong survival.
过去20年中，卵巢癌的年龄调整死亡率一直保持不变。最近通过淋巴管造影和腹腔镜检查对卵巢癌患者进行分期所获得的数据表明，许多看似局限期疾病的患者实际上在腹部已有隐匿性播散。这些新的分期技术加上对肿瘤间变组织学分级的判定，可能会使对患者预后的判断更为精确，从而能更好地设计治疗策略。放射治疗技术正在加以调整，试图治疗某些隐匿性疾病区域。许多单一化疗药物能够产生客观的肿瘤反应。初步数据表明，联合化疗可使客观缓解率高于单一药物治疗时的缓解率。需要更长时间的随访来确定联合化疗是否能延长生存期。
