ZIZZA F, CAMPBELL T J, REEVE E B
J Gen Physiol. 1959 Nov;43(2):397-413. doi: 10.1085/jgp.43.2.397.
When I(131)-albumin is given intravenously to rabbits, the radioactive breakdown products that are released into the plasma and urine can be extracted into acetone. Paper chromatography and paper electrophoresis show that about 80 per cent of these are I(131)-iodide and the remainder are organic I(131)-iodine compounds. When I(131)-iodide is given to rabbits taking iodide in their drinking water, the radioactivity is quantitatively excreted, without being accumulated in the tissues and without becoming attached to the plasma proteins. The rate of excretion can be defined by a first order rate process with a rate constant, a, ranging between 1 and 3day(-1). The organic I(131)-iodine compounds liberated during the metabolism of I(131)-albumin can be closely matched by a mixture of the organic I(131)-iodine compounds liberated during the metabolism of I(131)-monoiodotyrosine, I(131)-diiodotyrosine, and the amino acids released by digestion from I(131)-albumin. These organic I(131)-iodine compounds are not accumulated in the body and their radioactivity does not become attached to the plasma proteins. Their radioactivity is excreted as fast or faster than that of I(131)-iodide, and, to a satisfactory approximation, the same equations describing the excretion of I(131)-iodide with the same constants may be used for describing the excretion of the organic I(131)-iodine. These results permit improved estimates of the distribution and catabolism of I(131)-albumin.
给兔子静脉注射碘（131）-白蛋白后，释放到血浆和尿液中的放射性分解产物可被提取到丙酮中。纸层析和纸电泳显示，其中约80%是碘（131）-碘化物，其余是有机碘（131）-碘化合物。给饮用含碘水的兔子注射碘（131）-碘化物后，放射性物质定量排泄，不蓄积于组织中，也不与血浆蛋白结合。排泄速率可用一级速率过程定义，速率常数a在1至3天（-1）之间。碘（131）-白蛋白代谢过程中释放的有机碘（131）-碘化合物，可与碘（131）-单碘酪氨酸、碘（131）-二碘酪氨酸代谢过程中释放的有机碘（131）-碘化合物以及碘（131）-白蛋白消化释放的氨基酸的混合物紧密匹配。这些有机碘（131）-碘化合物不在体内蓄积，其放射性也不与血浆蛋白结合。它们的放射性排泄速度与碘（131）-碘化物相同或更快，并且，在令人满意的近似程度上，描述碘（131）-碘化物排泄的相同方程，使用相同的常数，可用于描述有机碘（131）-碘的排泄。这些结果有助于更准确地估计碘（131）-白蛋白的分布和分解代谢。
