伊洛前列素对犬脑动脉的舒张作用。
Relaxant effects on iloprost in canine cerebral artery.
作者信息
Zhang H, Weir B, Doi M, Kasuya H, Cook D
机构信息
Department of Surgery, University of Alberta, Edmonton, Canada.
出版信息
Can J Physiol Pharmacol. 1992 May;70(5):712-6. doi: 10.1139/y92-092.
Iloprost caused relaxation of rings of canine cerebral arteries precontracted with prostaglandin F2 alpha or the thromboxane A2 analogue U46619, but it was without effect on arteries precontracted with potassium chloride. Pretreatment with iloprost did not significantly affect the concentration-response curve to any agent. Contractile responses to oxyhemoglobin were completed relaxed by iloprost. In arteries from animals with moderate cerebrovascular spasm, the response to prostaglandin F2 alpha was also reduced by iloprost. The observation that iloprost relaxes the response to oxyhemoglobin to prostaglandin F2 alpha in spastic arteries may be of interest in the management of cerebral vasospasm.
依洛前列素可使预先用前列腺素F2α或血栓素A2类似物U46619预收缩的犬脑动脉环舒张，但对用氯化钾预收缩的动脉无作用。依洛前列素预处理对任何药物的浓度-反应曲线均无显著影响。依洛前列素可使对氧合血红蛋白的收缩反应完全舒张。在患有中度脑血管痉挛的动物的动脉中，依洛前列素也可降低对前列腺素F2α的反应。依洛前列素可使痉挛动脉中对氧合血红蛋白和前列腺素F2α的反应舒张，这一观察结果可能对脑血管痉挛的治疗有意义。
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