布米那福的急性毒性、细胞遗传学和胚胎毒性活性研究。

Investigations of the acute toxic, cytogenetic, and embryotoxic activity of buminafos.

作者信息

Nehéz M, Fischer G W, Scheufler H, Schmidt R, Sipos T, Dési I

机构信息

Department of Hygiene and Epidemiology, Albert Szent-Györgyi University Medical School, Szeged, Hungary.

出版信息

Ecotoxicol Environ Saf. 1992 Aug;24(1):13-6. doi: 10.1016/0147-6513(92)90030-7.

DOI:10.1016/0147-6513(92)90030-7

PMID:1385074

Abstract

The organophosphorus herbicide buminafos (O,O-dibutyl-(1-butylaminocyclohexyl)-phosphonate) was tested for its acute toxic, cytogenetic, and embryotoxic activity on different strains of mice. The oral LD50 value for male NMRI mice was determined to be 3500 mg/kg. Single oral doses of 175, 1000, and 2000 mg/kg did not cause any significant enhancement in the percentage of chromosome aberrations in bone marrow cells of male NMRI mice. After oral administration of 500 and 1000 mg/kg buminafos to pregnant Halle:DBA and Halle:AB mice at Days 6-15 of gestation no embryotoxic effects were observed. The cytogenetic inactivity of buminafos in the bone marrow chromosome assay corresponds to negative findings in other mutagenicity tests.

摘要

对有机磷除草剂布草磷（O,O -二丁基-(1 -丁基氨基环己基)-膦酸酯）在不同品系小鼠上进行了急性毒性、细胞遗传学和胚胎毒性活性测试。雄性NMRI小鼠的经口半数致死剂量（LD50）值测定为3500毫克/千克。175、1000和2000毫克/千克的单次经口剂量未导致雄性NMRI小鼠骨髓细胞染色体畸变百分比有任何显著增加。在妊娠第6 - 15天对怀孕的哈勒:DBA和哈勒:AB小鼠经口给予500和1000毫克/千克布草磷后，未观察到胚胎毒性作用。布草磷在骨髓染色体试验中的细胞遗传学无活性与其他致突变性试验的阴性结果一致。