Schiebler M L, Yankaskas B C, Tempany C, Holtz P, Zerhouni E
Department of Radiology, Hospital of the University of Pennsylvania, Philadelphia 19104.
Invest Radiol. 1992 Aug;27(8):575-7. doi: 10.1097/00004424-199208000-00002.
The authors compared the two most common presurgical tests now used for the preoperative staging of adenocarcinoma of the prostate, prostate-specific antigen (PSA) and magnetic resonance imaging (MRI).
One hundred consecutive radical retropubic prostatectomy patients were imaged at 1.5 Tesla before surgery with routine T1-weighted and T2-weighted transaxial images. The images were analyzed by two experienced radiologists for evidence of extracapsular disease. Radiologists rated each gland on a scale of 0 to 100 for the percentage likelihood of extracapsular disease based on its MRI appearance. Receiver operator characteristic (ROC) curves were plotted, and areas were calculated for the two radiologists and the preoperative PSA values.
Comparison of the areas of the ROC curves generated from the two radiologists and those from the preoperative PSA values showed no statistical difference.
In this series, radiologic interpretation of body coil MRI studies in those patients chosen for a radical retropubic prostatectomy was no better in staging adenocarcinoma of the prostate than simply using the preoperative PSA values.
作者比较了目前用于前列腺癌术前分期的两种最常用的术前检查方法，即前列腺特异性抗原（PSA）和磁共振成像（MRI）。
对100例连续接受耻骨后根治性前列腺切除术的患者在术前进行1.5特斯拉的磁共振成像检查，获取常规T1加权和T2加权横轴位图像。由两位经验丰富的放射科医生对图像进行分析，以寻找包膜外病变的证据。放射科医生根据腺体的MRI表现，对每个腺体包膜外病变可能性的百分比在0至100的范围内进行评分。绘制受试者操作特征（ROC）曲线，并计算两位放射科医生以及术前PSA值的曲线下面积。
两位放射科医生生成的ROC曲线面积与术前PSA值生成的ROC曲线面积比较，无统计学差异。
在本系列研究中，对于那些选择接受耻骨后根治性前列腺切除术的患者，体部线圈MRI检查的影像学解读在前列腺癌分期方面并不比单纯使用术前PSA值更好。
