药物引起的脑脊液和尾状核中5-羟色胺吲哚化合物浓度的变化。
Drug-induced changes in the concentration of 5-OR indolyl compounds in cerebrospinal fluid and caudate nucleus.
作者信息
ASHCROFT G W, SHARMAN D F
出版信息
Br J Pharmacol Chemother. 1962 Aug;19(1):153-60. doi: 10.1111/j.1476-5381.1962.tb01436.x.
Abstract
The effects of reserpine and imipramine on the concentration of indolyl compounds bearing an OR group in position 5 (5-OR indolyl compounds) in the cerebrospinal fluid and the caudate nucleus of the dog have been studied. Reserpine was shown to produce an increase in the concentration of these compounds in the cerebrospinal fluid. In the caudate nucleus reserpine produced a fall in the concentration of the basic 5-OR indolyl compounds accompanied by an equivalent increase in the concentration of acidic 5-OR indolyl compounds. No significant change in the concentration of 5-OR indolyl compounds in the cerebrospinal fluid was observed after treatment with imipramine.
摘要
已经研究了利血平和丙咪嗪对犬脑脊液和尾状核中5位带有OR基团的吲哚类化合物（5-OR吲哚类化合物）浓度的影响。结果显示，利血平可使脑脊液中这些化合物的浓度升高。在尾状核中，利血平使碱性5-OR吲哚类化合物的浓度降低，同时酸性5-OR吲哚类化合物的浓度相应升高。用丙咪嗪治疗后，未观察到脑脊液中5-OR吲哚类化合物的浓度有显著变化。
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