Bamberg-Thalén B, Linde-Forsberg C
Department of Medicine and Surgery, Swedish University of Agricultural Sciences, Uppsala.
Zentralbl Veterinarmed A. 1992 May;39(4):264-70. doi: 10.1111/j.1439-0442.1992.tb00182.x.
Three dogs were treated with medroxyprogesterone acetate (MPA) and three were treated with ethinylestradiol. The results indicate that at a dosage of 3-4.8 mg/kg b.w. MPA does not have any detrimental effects on hemogram, testicles or semen quality, whereas ethinylestradiol (2 micrograms/kg b.w./day) can negatively affect both testes and semen quality. Both drugs can cause a decrease in prostatic size in clinically healthy dogs. Measurements of peripheral serum testosterone levels indicate that at the dosages used, testosterone levels are depressed considerably more by ethinylestradiol than by MPA.
三只狗接受了醋酸甲羟孕酮（MPA）治疗，三只狗接受了炔雌醇治疗。结果表明，在3 - 4.8毫克/千克体重的剂量下，MPA对血常规、睾丸或精液质量没有任何有害影响，而炔雌醇（2微克/千克体重/天）会对睾丸和精液质量产生负面影响。两种药物都会使临床健康犬的前列腺体积减小。外周血清睾酮水平的测量表明，在所使用的剂量下，炔雌醇比MPA更能显著降低睾酮水平。
