离体肠管和输精管标本中交感神经机制的研究。
Studies on sympathetic mechanisms in isolated intestinal and vas deferens preparations.
作者信息
BENTLEY G A
出版信息
Br J Pharmacol Chemother. 1962 Aug;19(1):85-98. doi: 10.1111/j.1476-5381.1962.tb01429.x.
Abstract
The effects of various drugs which block sympathetic nerves have been studied in Finkleman preparations of rabbit and cat ileum. Contractile responses could be produced in many cases after the normal inhibitory responses to periarterial nerve stimulation had been blocked. In almost all cases this contractile response was abolished by ganglion-blocking drugs. The normal rabbit ileum Finkleman preparation was found to behave differently towards bretylium than do preparations taken from animals treated with reserpine. The block of the guinea-pig isolated hypogastric vas deferens preparation caused by hemicholinium HC-3 was found to be reversed in the presence of noradrenaline, histamine, or 5-hydroxytryptamine, as was the block caused by guanethidine and bretylium. The results are discussed in relation to the Burn-Rand theory of sympathetic nerve mechanism.
摘要
在兔和猫回肠的芬克曼（Finkleman）标本中研究了各种阻断交感神经的药物的作用。在对动脉周围神经刺激的正常抑制反应被阻断后，在许多情况下可产生收缩反应。几乎在所有情况下，这种收缩反应都被神经节阻断药物消除。发现正常兔回肠芬克曼标本对溴苄铵的反应与从用利血平处理过的动物获取的标本不同。发现，在去甲肾上腺素、组胺或5-羟色胺存在的情况下，由半胱氨酸HC-3引起的豚鼠离体腹下输精管标本的阻断作用会被逆转，胍乙啶和溴苄铵引起的阻断作用也是如此。结合伯恩-兰德（Burn-Rand）交感神经机制理论对结果进行了讨论。
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