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PREGANGLIONIC AND POSTGANGLIONIC STIMULATION OF THE GUINEA-PIG ISOLATED VAS DEFERENS PREPARATION.豚鼠离体输精管标本的节前和节后刺激
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Effects of cocaine and of monoamine oxidase and catechol-o-methyl transferase inhibitors on transmission to the guinea-pig vas deferens.可卡因以及单胺氧化酶和儿茶酚 - O - 甲基转移酶抑制剂对豚鼠输精管传递的影响。
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本文引用的文献

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Pseudomotor contractures after degeneration of the facial nerve.面神经变性后的假性运动性挛缩。
J Physiol. 1931 Sep 18;73(1):54-66. doi: 10.1113/jphysiol.1931.sp002796.
2
On the nature of inhibition in the intestine.论肠道抑制的本质。
J Physiol. 1930 Sep 18;70(2):145-57. doi: 10.1113/jphysiol.1930.sp002683.
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Fluid electrodes with a rubber diaphragm.带有橡胶隔膜的流体电极。
J Physiol. 1951 Dec 28;115(4):61-2 P.
4
Effect of guanethidine in revealing cholinergic sympathetic fibres.胍乙啶在显示胆碱能交感神经纤维方面的作用。
Br J Pharmacol Chemother. 1961 Oct;17(2):245-60. doi: 10.1111/j.1476-5381.1961.tb01285.x.
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Spontaneous potential at sympathetic nerve endings in smooth muscle.平滑肌中交感神经末梢的自发电位。
J Physiol. 1962 Mar;160(3):446-60. doi: 10.1113/jphysiol.1962.sp006858.
6
Norepinephrine depletion as a possible mechanism of action of guanethidine (SU 5864), a new hypotensive agent.去甲肾上腺素耗竭作为新型降压药胍乙啶（SU 5864）一种可能的作用机制。
Proc Soc Exp Biol Med. 1960 Apr;103:871-2. doi: 10.3181/00379727-103-25702.
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Sympathetic postganglionic cholinergic fibres.交感神经节后胆碱能纤维。
Br J Pharmacol Chemother. 1960 Mar;15(1):56-66. doi: 10.1111/j.1476-5381.1960.tb01210.x.
8
The actions of bretylium: adrenergic neurone blocking and other effects.溴苄铵的作用：肾上腺素能神经元阻滞及其他作用。
Br J Pharmacol Chemother. 1959 Dec;14(4):536-48. doi: 10.1111/j.1476-5381.1959.tb00961.x.
9
The selective accumulation of bretylium in sympathetic ganglia and their postganglionic nerves.溴苄铵在交感神经节及其节后神经中的选择性蓄积。
Br J Pharmacol Chemother. 1960 Jun;15(2):265-70. doi: 10.1111/j.1476-5381.1960.tb01242.x.
10
Augmentation of the pressor response to guanethedine by inhibition of catechol O-methyltransferase.通过抑制儿茶酚 - O - 甲基转移酶增强对胍乙啶的升压反应。
Nature. 1961 Feb 11;189:490-1. doi: 10.1038/189490a0.

离体肠管和输精管标本中交感神经机制的研究。

Studies on sympathetic mechanisms in isolated intestinal and vas deferens preparations.

作者信息

BENTLEY G A

出版信息

Br J Pharmacol Chemother. 1962 Aug;19(1):85-98. doi: 10.1111/j.1476-5381.1962.tb01429.x.

DOI:10.1111/j.1476-5381.1962.tb01429.x
PMID:13867378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1482230/
Abstract

The effects of various drugs which block sympathetic nerves have been studied in Finkleman preparations of rabbit and cat ileum. Contractile responses could be produced in many cases after the normal inhibitory responses to periarterial nerve stimulation had been blocked. In almost all cases this contractile response was abolished by ganglion-blocking drugs. The normal rabbit ileum Finkleman preparation was found to behave differently towards bretylium than do preparations taken from animals treated with reserpine. The block of the guinea-pig isolated hypogastric vas deferens preparation caused by hemicholinium HC-3 was found to be reversed in the presence of noradrenaline, histamine, or 5-hydroxytryptamine, as was the block caused by guanethidine and bretylium. The results are discussed in relation to the Burn-Rand theory of sympathetic nerve mechanism.

摘要

在兔和猫回肠的芬克曼（Finkleman）标本中研究了各种阻断交感神经的药物的作用。在对动脉周围神经刺激的正常抑制反应被阻断后，在许多情况下可产生收缩反应。几乎在所有情况下，这种收缩反应都被神经节阻断药物消除。发现正常兔回肠芬克曼标本对溴苄铵的反应与从用利血平处理过的动物获取的标本不同。发现，在去甲肾上腺素、组胺或5-羟色胺存在的情况下，由半胱氨酸HC-3引起的豚鼠离体腹下输精管标本的阻断作用会被逆转，胍乙啶和溴苄铵引起的阻断作用也是如此。结合伯恩-兰德（Burn-Rand）交感神经机制理论对结果进行了讨论。