Mrázek J, Kypr J
Institute of Biophysics, Czechoslovak Academy of Sciences, Brno.
Comput Appl Biosci. 1992 Aug;8(4):401-4. doi: 10.1093/bioinformatics/8.4.401.
This paper presents a simple program for interactive searching for nucleotide sequences that may code for the helix-turn-helix, zinc finger or leucine zipper motifs in proteins. The helix-turn-helix motifs are predicted using the recently published method of Dodd and Egan, while zinc fingers and leucine zippers are searched for by our original methods. DNABIND is shown to detect all four known helix-turn-helix motifs in bacteriophage lambda genes and both zinc fingers of the adr1 gene of yeast.
本文介绍了一个简单的程序，用于交互式搜索可能编码蛋白质中螺旋-转角-螺旋、锌指或亮氨酸拉链基序的核苷酸序列。螺旋-转角-螺旋基序采用多德和伊根最近发表的方法进行预测，而锌指和亮氨酸拉链则通过我们的原始方法进行搜索。结果表明，DNABIND程序能够检测出噬菌体λ基因中所有四个已知的螺旋-转角-螺旋基序以及酵母adr1基因的两个锌指。
