Hundt M, Schmidt R E
Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover.
Immun Infekt. 1992 Jul;20(3):89-90.
PMN express primary two Fc gamma receptors for IgG immune complexes. Fc gamma RII is a transmembraneous molecule in contrast to Fc gamma RIII on PMN which is GPI-linked. In spite of the different membrane linkage both Fc gamma R use calcium as an intracellular signal. Cross-linking of Fc gamma RIII is more effective for induction of H2O2 production than Fc gamma RII. Monoclonal IgG1x cryoglobulin complexes activate PMN via Fc gamma RIII as shown by calcium mobilization and H2O2 production.
中性粒细胞表达针对IgG免疫复合物的两种主要Fcγ受体。与中性粒细胞上通过糖基磷脂酰肌醇（GPI）连接的FcγRIII不同，FcγRII是一种跨膜分子。尽管膜连接方式不同，但两种Fcγ受体都利用钙作为细胞内信号。FcγRIII的交联在诱导过氧化氢产生方面比FcγRII更有效。如钙动员和过氧化氢产生所示，单克隆IgG1x冷球蛋白复合物通过FcγRIII激活中性粒细胞。
