突变对连锁不平衡的影响。

The effect of mutation on linkage disequilibrium.

作者信息

Carothers A D, Wright A F

机构信息

Medical Research Council Human Genetics Unit, Western General Hospital, Edinburgh.

出版信息

Ann Hum Genet. 1992 May;56(2):155-8. doi: 10.1111/j.1469-1809.1992.tb01141.x.

DOI:10.1111/j.1469-1809.1992.tb01141.x

PMID:1386967

Abstract

The standard formula for the approach to linkage equilibrium between two diallelic loci, initially at disequilibrium, is expressed in terms of their probability of recombination (Li, 1955). By a simple extension, we show how to incorporate the effects of mutation at one or both loci. It can thereby be inferred that in general these effects are unlikely to be of major importance, contrary to some recent suggestions.

摘要

两个双等位基因位点之间最初处于不平衡状态时达到连锁平衡的标准公式，是根据它们的重组概率来表示的（李，1955年）。通过一个简单的扩展，我们展示了如何纳入一个或两个位点的突变效应。由此可以推断，一般来说，与最近的一些观点相反，这些效应不太可能具有重要意义。