人类细胞周期蛋白D3基因（CCND3）定位于6号染色体p----q13区。
Assignment of the human cyclin D3 gene (CCND3) to chromosome 6p----q13.
作者信息
Motokura T, Yi H F, Kronenberg H M, McBride O W, Arnold A
机构信息
Endocrine Unit, Massachusetts General Hospital, Boston 02114.
出版信息
Cytogenet Cell Genet. 1992;61(1):5-7. doi: 10.1159/000133359.
The PRAD1/cyclin D1 gene (CCND1), a member of the D-type cyclin gene family, has been implicated as a protooncogene in parathyroid, lymphoid, and mammary tumors. We cloned and mapped another member of this family, the human cyclin D3 gene (CCND3), to chromosome 6p----q13 using human x rodent hybrids. This assignment raises the hypothesis that cyclin D3 may be involved in the pathogenesis of human neoplasms with abnormalities of chromosome 6.
PRAD1/细胞周期蛋白D1基因（CCND1）是D型细胞周期蛋白基因家族的成员，已被认为是甲状旁腺、淋巴和乳腺肿瘤中的原癌基因。我们利用人-啮齿动物杂种细胞克隆了该家族的另一个成员——人细胞周期蛋白D3基因（CCND3），并将其定位于6号染色体p----q13区域。这一定位提出了一个假说，即细胞周期蛋白D3可能参与了6号染色体异常的人类肿瘤的发病机制。
Zotero 插件