Fok T F, Yin J A, Yuen P M
Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin.
Acta Paediatr. 1992 Mar;81(3):204-6. doi: 10.1111/j.1651-2227.1992.tb12204.x.
The plasma concentrations of antithrombin III, protein C and protein S in capillary and venous blood samples obtained simultaneously from 30 neonates were compared in order to determine the suitability of using capillary blood for estimation of these proteins with anticoagulant action. Our findings showed that while capillary and venous blood did not differ significantly in antithrombin III functional activity and protein C antigen levels, the capillary samples had significantly lower protein C functional activity and higher antithrombin III antigen level. Protein S antigen level was also significantly higher in the capillary samples although the difference was relatively small. The capillary and venous concentrations of the binding protein of protein S, C4b binding protein, were almost identical.
为了确定使用毛细血管血来评估这些具有抗凝作用的蛋白质的适用性，对同时从30名新生儿采集的毛细血管血和静脉血样本中的抗凝血酶III、蛋白C和蛋白S的血浆浓度进行了比较。我们的研究结果表明，虽然毛细血管血和静脉血在抗凝血酶III功能活性和蛋白C抗原水平上没有显著差异，但毛细血管血样本的蛋白C功能活性显著较低，抗凝血酶III抗原水平较高。蛋白S抗原水平在毛细血管血样本中也显著较高，尽管差异相对较小。蛋白S的结合蛋白C4b结合蛋白的毛细血管血和静脉血浓度几乎相同。
