Rao M S, Subbarao V, Yeldandi A V, Reddy J K
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611-3008.
Cancer Lett. 1992 Aug 14;65(2):123-6. doi: 10.1016/0304-3835(92)90155-o.
The incidence of spontaneous Leydig cell tumors of testis is very high in old F-344 rats. We have examined the effect of dehydroepiandrosterone (DHEA), a steroid hormone with antimitotic and anticarcinogenic properties, on spontaneous Leydig cell tumorigenesis. Fifteen-week-old male F-344 rats were fed a diet containing DHEA (0.45% w/w) for 84 weeks. At the termination of experiment none of the 13 rats had Leydig cell hyperplasia or Leydig cell tumors. All the eight control rats of comparable age had Leydig cell tumors. These findings suggest that DHEA is a potent inhibitor of spontaneous Leydig cell tumors of testis in aged rats.
老年F-344大鼠睾丸自发性莱迪希细胞瘤的发生率非常高。我们研究了具有抗有丝分裂和抗癌特性的甾体激素脱氢表雄酮（DHEA）对自发性莱迪希细胞瘤发生的影响。给15周龄的雄性F-344大鼠喂食含DHEA（0.45% w/w）的饲料84周。实验结束时，13只大鼠中无一出现莱迪希细胞增生或莱迪希细胞瘤。所有8只年龄相当的对照大鼠都有莱迪希细胞瘤。这些发现表明，DHEA是老年大鼠睾丸自发性莱迪希细胞瘤的有效抑制剂。
