尼可地尔在运动期间对交感神经系统活动的抑制作用。

Suppression of sympathetic nervous system activity by nicorandil during exercise.

Ogino K, Kinugawa T, Noguchi N, Kitamura H, Matsumoto T, Miyakoda H, Kotake H, Mashiba H

First Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan.

Gen Pharmacol. 1992 May;23(3):325-9. doi: 10.1016/0306-3623(92)90090-7.

Abstract

Treadmill testing was done and plasma epinephrine and norepinephrine were measured during exercise and recovery in 21 patients with coronary artery disease given nicorandil. 2. Epinephrine levels during exercise did not change significantly with nicorandil, but the percent change in epinephrine with nicorandil tended to be lower during exercise. 3. Norepinephrine levels after exercise were suppressed with nicorandil (with, 424 +/- 15 pg/ml; without, 760 +/- 16, P less than 0.05). 4. Also, the percent change in norepinephrine with nicorandil was significantly decreased during exercise and recovery (with, 259 +/- 11%; without, 555 +/- 19, P less than 0.01). 5. Therefore, nicorandil suppressed the sympathetic nervous system hyper-response to exercise.

摘要

对21例服用尼可地尔的冠心病患者进行了跑步机测试，并在运动及恢复过程中测定了血浆肾上腺素和去甲肾上腺素水平。2. 运动期间，尼可地尔对肾上腺素水平无显著影响，但服用尼可地尔期间运动时肾上腺素的变化百分比趋于降低。3. 运动后，尼可地尔可抑制去甲肾上腺素水平（服用尼可地尔组，424±15 pg/ml；未服用组，760±16，P<0.05）。4. 此外，服用尼可地尔期间运动及恢复过程中去甲肾上腺素的变化百分比显著降低（服用组，259±11%；未服用组，555±19，P<0.01）。5. 因此，尼可地尔可抑制交感神经系统对运动的过度反应。