NAN - 190对大鼠中缝背核神经元作用的细胞内研究。
An intracellular study of the action of NAN-190 on neurons in the dorsal raphe nucleus of the rat.
作者信息
Hodgkiss J P, Dawson I M, Kelly J S
机构信息
Department of Pharmacology, University of Edinburgh, UK.
出版信息
Brain Res. 1992 Mar 27;576(1):157-61. doi: 10.1016/0006-8993(92)90623-h.
Intracellular recordings have been made from neurons in the dorsal raphe (DR) nucleus of the rat to determine the mechanism of action of the arylpiperazine compound NAN-190. Application of NAN-190 (50 microM) alone most frequently caused a hyperpolarization accompanied by a fall in RM and reduced the response to 5-HT and 8-OH-DPAT. After pretreatment of the preparation with the 5-HT-uptake blocker citalopram (10 microM) NAN-190 exerted an excitatory effect. It is concluded that NAN-190 is a partial agonist in the DR nucleus.
已对大鼠中缝背核（DR）中的神经元进行细胞内记录，以确定芳基哌嗪化合物NAN - 190的作用机制。单独应用NAN - 190（50微摩尔）最常引起超极化，同时伴有膜电阻（RM）下降，并降低对5 - 羟色胺（5 - HT）和8 - 羟基 - 二丙基氨基四氢萘（8 - OH - DPAT）的反应。在用5 - HT摄取阻滞剂西酞普兰（10微摩尔）预处理标本后，NAN - 190发挥兴奋作用。得出的结论是，NAN - 190在中缝背核中是一种部分激动剂。
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