Sparks D L, Hunsaker J C
Alzheimer's Disease Research Center/Sanders-Brown Center on Aging, Lexington, KY 40536-0230.
J Neurol Sci. 1992 May;109(1):77-82. doi: 10.1016/0022-510x(92)90097-5.
We have histopathologically investigated the hippocampal formation in 4 individuals with Down's syndrome (DS), 7 control individuals, and 3 individuals dying after being in coma 3-7 days. Adjacent sections of brain were stained by the Bielschowsky method and by ALZ-50 immunocytochemical methods. ALZ-50 immunoreactive neurons were found in each individual with DS and only in the control infants. Neither ALZ-50-immunoreactive features nor abnormal silver-positive features stained by the Bielschowsky method were found in the adolescent or young adult controls or coma patients. Diffuse form senile plaques (SP) were found only in the oldest DS individual. The data suggest that ALZ-50 reactive neurons persist during the life of an individual with DS and may precede the formation of SP.
我们对4例唐氏综合征（DS）患者、7例对照个体以及3例昏迷3 - 7天后死亡的个体的海马结构进行了组织病理学研究。大脑相邻切片用 Bielschowsky 法和 ALZ - 50免疫细胞化学方法染色。在每例DS患者个体以及仅在对照婴儿中发现了ALZ - 50免疫反应性神经元。在青少年或青年对照个体以及昏迷患者中，未发现ALZ - 50免疫反应性特征或 Bielschowsky 法染色的异常银阳性特征。仅在年龄最大的DS个体中发现了弥漫性老年斑（SP）。数据表明，ALZ - 50反应性神经元在DS患者个体的生命过程中持续存在，且可能先于SP的形成。
