CARTER A, MARTIN N H
J Clin Pathol. 1962 Jan;15(1):69-72. doi: 10.1136/jcp.15.1.69.
Sialic acid levels in normal and pathological sera estimated by the improved Svennerholm technique are reported. The increased levels demonstrable in rheumatoid arthritis, cirrhosis, gamma myelomata, and macroglobulinaemia are demonstrated as being explicable on the basis of increased production of proteins of normal sialic content.Tentative reasons are given for the possibility that abnormal binding of sialic acid may occur in nephrotic sera and sera from beta globulin myelomata. The latter may be confused with ;macroglobulinaemia'.
报告了用改良的斯文纳霍尔姆技术测定的正常和病理血清中的唾液酸水平。类风湿性关节炎、肝硬化、γ骨髓瘤和巨球蛋白血症中可证实的水平升高被证明是由于正常唾液酸含量的蛋白质产生增加所致。对于肾病血清和β球蛋白骨髓瘤血清中可能发生唾液酸异常结合的可能性给出了初步原因。后者可能与“巨球蛋白血症”混淆。