Weiss J P, Lorenzo F V, Campbell C D, Myerowitz R L, Webster M W
J Thorac Cardiovasc Surg. 1977 Apr;73(4):630-6.
In 11 dogs the bacteriologic and morphologic reaction of arterial prostheses made of expanded polytetrafluoroethylene (Gore-Tex) to an induced Staphylococcus aureus septicemia at time of graft implantation was evaluated and compared to that observed with Dacron grafts in 10 dogs. Graft infection developed in all dogs, manifested by positive blood and graft cultures. Grafts, however, could be clearly classified as either histologically infected or uninfected with a marked difference in the pattern of positive blood cultures. Histologically uninfected grafts in general demonstrated the tissue ingrowth and neointima formation which characterize Gore-Tex despite positive graft culture. The appearance of overt histologic infection was correlated with failure of a neointima to develop. Gore-Tex did not loose its structural integrity despite frank injection. The use of the Gore-Tex in the face of overt infection cannot be supported.
对11只狗体内由膨体聚四氟乙烯（戈尔特斯）制成的动脉假体在植入时对诱发的金黄色葡萄球菌败血症的细菌学和形态学反应进行了评估，并与10只狗体内涤纶假体的观察结果进行了比较。所有狗都发生了移植感染，表现为血液和移植组织培养呈阳性。然而，移植组织可明确分为组织学上感染或未感染，血液培养阳性模式存在显著差异。尽管移植组织培养呈阳性，但组织学上未感染的移植组织通常表现出戈尔特斯特有的组织长入和新内膜形成。明显的组织学感染的出现与新内膜未能形成有关。尽管有明显的感染，戈尔特斯并未失去其结构完整性。面对明显感染时使用戈尔特斯是不可取的。
