Suminaga M, Furue H, Taguchi T, Niitani H, Ota K, Tsukagoshi S, Ariyoshi Y, Ikeda M, Akasaka Y, Ohta J
Department of Internal Medicine IV, Teikyo University School of Medicine, Kawasaki, Japan.
Gan To Kagaku Ryoho. 1992 Sep;19(11):1879-90.
The anti-emetic effects, safety and usefulness of ondansetron, a 5-HT3 receptor antagonist, given orally once daily for 3-5 consecutive days, were investigated in patients receiving a high single dose (greater than or equal to 50 mg/m2 or 75 mg/body) or lower multiple doses (greater than or equal to 15-20 mg/m2/day for 3-5 consecutive days) of cisplatin. Ondansetron 4 mg was administered orally once daily for 3-5 consecutive days. Efficacy rates in controlling nausea and emesis over the 3-5 days were 77.3% (17/22 cases) and 66.7% (6/9 cases) in patients receiving a high single dose and lower multiple doses of cisplatin, respectively. Side effects were observed in 2 cases (headache and elevation of blood pressure in one case and only headache in the other case.). Abnormality in clinical laboratory findings was observed in 1 case. From the above, ondansetron, showing high efficacy by oral administration 4 mg once daily for 3-5 consecutive days, without any problem in safety, was considered to be a useful anti-emetic agent.
对接受高单次剂量（大于或等于50mg/m²或75mg/体）或低多次剂量（连续3 - 5天大于或等于15 - 20mg/m²/天）顺铂治疗的患者，研究了5 - HT3受体拮抗剂昂丹司琼连续3 - 5天每日口服一次的止吐效果、安全性和有效性。昂丹司琼4mg连续3 - 5天每日口服一次。接受高单次剂量和顺铂低多次剂量治疗的患者在3 - 5天内控制恶心和呕吐的有效率分别为77.3%（17/22例）和66.7%（6/9例）。观察到2例副作用（1例头痛和血压升高，另1例仅头痛）。1例临床实验室检查结果异常。综上所述，昂丹司琼连续3 - 5天每日口服4mg显示出高效，且安全性无任何问题，被认为是一种有用的止吐药。
