Smirnova N B
Probl Endokrinol (Mosk). 1976 Nov-Dec;22(6):88-92.
A study was made of the ways of transformation of pregnenolone into sulfated androgens in the virilizing tumours of the human adrenal glands. Formation of sulfates of pregnenolone, 17alpha-on-pregnenolone, dehydroepiandrosterone, delta5-androsten-3beta, 17beta-diol, and testosterone was revealed in the tissue of the adrenal gland tumours. The principal sulfate forming in the tumour tissue was dehydroepiandrosterone-sulfate (DEAS). Analysis of the time changes of the pregnenolone label in the sulfates under study and in the corresponding free compounds showed that DEAS formed chiefly through the free dehydroepiandrosterone. Formation of sulfates of 17alpha-on-pregnenolone, delta5-androsten-3beta, 17beta-diol, testosterone coursed along the route of the both sulfated and free precursors.
对人类肾上腺雄激素化肿瘤中孕烯醇酮转化为硫酸化雄激素的途径进行了研究。在肾上腺肿瘤组织中发现了孕烯醇酮、17α-羟孕烯醇酮、脱氢表雄酮、δ5-雄烯-3β,17β-二醇和睾酮的硫酸盐形成。肿瘤组织中形成的主要硫酸盐是硫酸脱氢表雄酮（DEAS）。对所研究的硫酸盐以及相应游离化合物中孕烯醇酮标记的时间变化分析表明，DEAS主要通过游离脱氢表雄酮形成。17α-羟孕烯醇酮、δ5-雄烯-3β,17β-二醇、睾酮的硫酸盐形成是通过硫酸化和游离前体两条途径进行的。
