M'Harzi M, Jarrard L E
Laboratoire de Psychophysiologie, Université Paris, France.
Behav Brain Res. 1992 Aug 10;49(2):159-65. doi: 10.1016/s0166-4328(05)80160-3.
Rats with lesions limited to either the medial septal (MS) or dorsolateral septal (LS) nuclei were trained on a place and cue version of the radial maze using a procedure that permits determination of both reference memory (RM) and working memory (WM). Following training the presence or absence of hippocampal theta for MS and LS groups was determined. The results showed that both MS- and LS-lesioned rats were impaired in acquisition. Specifically, the pattern of results indicated a general impairment in working memory that was found on both the place and cue tasks together with impaired acquisition of the place (but not the cue) task. While both septal lesion groups evidenced a similar impairment, rats in the MS group made more errors than LS rats on several components of the tasks. Electroencephalographic recordings revealed that hippocampal theta was not affected in the LS group but was abolished in rats with MS lesions. Thus, it appears that the functional role of the septo-hippocampal system cannot be fully described by a single mechanism or process but rather several processes seem to be affected when the septal area is damaged.
对内侧隔核（MS）或背外侧隔核（LS）损伤的大鼠进行放射状迷宫的位置和线索版本训练，采用一种允许同时测定参考记忆（RM）和工作记忆（WM）的程序。训练后，确定MS组和LS组海马θ波的有无。结果表明，MS组和LS组损伤大鼠在习得方面均受损。具体而言，结果模式表明，在位置和线索任务上均发现工作记忆普遍受损，同时位置（而非线索）任务的习得也受损。虽然两个隔核损伤组都表现出类似的损伤，但MS组大鼠在任务的几个组成部分上比LS组大鼠犯的错误更多。脑电图记录显示，LS组海马θ波未受影响，但MS损伤大鼠的海马θ波消失。因此，似乎隔海马系统的功能作用不能用单一机制或过程来完全描述，而是当隔区受损时，似乎有几个过程受到影响。
