面貌一新的古老微生物：分子生物学与新型疫苗设计
Old microbes with new faces: molecular biology and the design of new vaccines.
作者信息
Connell N, Stover C K, Jacobs W R
机构信息
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 1046.
出版信息
Curr Opin Immunol. 1992 Aug;4(4):442-8. doi: 10.1016/s0952-7915(06)80036-1.
PMID:1388846
Abstract
Rational approaches to the design of live attenuated bacterial and viral recombinant vaccine strains are leading to the manipulation of old vaccines and the generation of new ones. The two basic problems to be solved are attenuation of pathogenic strains, and the stable expression of foreign antigens.
摘要
减毒活细菌和病毒重组疫苗株设计的合理方法正在推动旧疫苗的改良和新疫苗的研发。需要解决的两个基本问题是致病菌株的减毒以及外源抗原的稳定表达。
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