Mason H S, Arntzen C J
Boyce Thompson Institute for Plant Research, Ithaca, NY 14853-1801, USA.
Trends Biotechnol. 1995 Sep;13(9):388-92. doi: 10.1016/S0167-7799(00)88986-6.
Transgenic plants that express foreign proteins with industrial or pharmaceutical value represent an economical alternative to fermentation-based production systems. Specific vaccines have been produced in plants as a result of the transient or stable expression of foreign genes. It has recently been shown that genes encoding antigens of bacterial and viral pathogens can be expressed in plants in a form in which they retain native immunogenic properties. Transgenic potato tubers expressing a bacterial antigen stimulated humoral and mucosal immune responses when they were provided as food. These results provide 'proof of concept' for the use of plants as a vehicle to produce vaccines.
表达具有工业或药用价值的外源蛋白的转基因植物，是基于发酵的生产系统的一种经济替代方案。由于外源基因的瞬时或稳定表达，已经在植物中生产出了特定疫苗。最近有研究表明，编码细菌和病毒病原体抗原的基因可以在植物中以保留天然免疫原性的形式表达。当将表达细菌抗原的转基因马铃薯块茎作为食物提供时，它们会刺激体液和黏膜免疫反应。这些结果为利用植物作为生产疫苗的载体提供了“概念验证”。
