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小鼠体内具有不同分子大小的抗体。

Antibodies with differing molecular sizes in mice.

作者信息

FAHEY J L, HUMPHREY J H

出版信息

Immunology. 1962 Jan;5(1):104-9.

PMID:13891304
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1424186/
Abstract

The antibody responses of CH mice to haemocyanin, pneumococcal polysaccharide (SSS III) and sheep erythrocytes were studied after a single intravenous administration. Serum antibody against each antigen was present on the fifth, but not on the third day. Antibodies against haemocyanin and against SSS III migrated electrophoretically as γ globulins and had the ultracentrifugal sedimentation properties of 6.5S globulins. Sheep erythrocyte haemolysins were largely γ macroglobulins which sedimented in the ultracentrifuge in the manner of 18S globulins. A small proportion of haemolysin activity was found among the 6.5S γ globulins.

摘要

在单次静脉注射后，研究了CH小鼠对血蓝蛋白、肺炎球菌多糖（SSS III）和绵羊红细胞的抗体反应。针对每种抗原的血清抗体在第5天出现，但在第3天未出现。抗血蓝蛋白和抗SSS III的抗体在电泳中作为γ球蛋白迁移，并具有6.5S球蛋白的超速离心沉降特性。绵羊红细胞溶血素主要是γ巨球蛋白，在超速离心机中以18S球蛋白的方式沉降。在6.5Sγ球蛋白中发现了一小部分溶血素活性。

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本文引用的文献

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Differences in primary and secondary immunizability of inbred mice strains.近交系小鼠品系的初次和二次免疫反应性差异。
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Separation of 6.6S and 18S gamma globulins with isohemagglutinin activity.具有同种血凝素活性的6.6S和18Sγ球蛋白的分离
J Lab Clin Med. 1960 Jun;55:912-6.
3
Human gamma globulin fractionation on anion exchange cellulose columns.人γ-球蛋白在阴离子交换纤维素柱上的分级分离。
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The significance of multiple antibody components in serum of immunized rabbits.免疫兔血清中多种抗体成分的意义。
Immunology. 1960 Oct;3(4):336-51.
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Electrophoretic and ultracentrifugal studies on rabbit hemolysins.关于兔溶血素的电泳和超速离心研究。
J Immunol. 1956 Dec;77(6):396-404.
6
Separation of complete and incomplete Rh antibodies by centrifugation.通过离心分离完全和不完全Rh抗体。
Science. 1955 Dec 2;122(3179):1091-2. doi: 10.1126/science.122.3179.1091-b.
7
Micromethods for the study of proteins and antibodies. I. Procedure and general applications of hemagglutination and hemagglutination-inhibition reactions with tannic acid and protein-treated red blood cells.蛋白质和抗体研究的微量方法。I. 用鞣酸和蛋白质处理的红细胞进行血凝和血凝抑制反应的程序及一般应用。
J Immunol. 1954 May;72(5):360-7.