FAHEY J L, HUMPHREY J H
Immunology. 1962 Jan;5(1):110-5.
The response to primary antigenic stimulation was measured in CH mice bearing two types of plasma-cell tumours, the 5563 tumour producing γ-type myeloma proteins and the 5674 tumour producing β-type myeloma proteins. Haemocyanin and pneumococcus type III polysaccharide, which produce 6.5S antibodies, and sheep erythrocytes, which produce 18S haemolysins, were used. Levels of serum antibody to all antigens were low in mice with the plasma-cell tumours, compared with those in normal mice, or mice with a mammary carcinoma. The larger the tumour, the lower were the antibody levels. Antibody levels were lower generally with the 5563 tumours than with the 5647 plasma-cell tumours of similar weight. Although rapid catabolism of normal gamma globulins contributes to the low level of serum antibody in mice with the 5563 γ-type tumour, diminished responsiveness of the antigen-susceptible cells appears to be the principal factor in the impaired antibody response in mice with the 5647 β-type plasma-cell tumour.
在携带两种浆细胞瘤的CH小鼠中检测对初次抗原刺激的反应，这两种浆细胞瘤分别是产生γ型骨髓瘤蛋白的5563肿瘤和产生β型骨髓瘤蛋白的5674肿瘤。使用了能产生6.5S抗体的血蓝蛋白和III型肺炎球菌多糖，以及能产生18S溶血素的绵羊红细胞。与正常小鼠或患有乳腺癌的小鼠相比，患有浆细胞瘤的小鼠针对所有抗原的血清抗体水平较低。肿瘤越大，抗体水平越低。一般来说，5563肿瘤小鼠的抗体水平低于重量相似的5647浆细胞瘤小鼠。虽然正常γ球蛋白的快速分解代谢导致了5563γ型肿瘤小鼠血清抗体水平较低，但抗原敏感细胞反应性降低似乎是5647β型浆细胞瘤小鼠抗体反应受损的主要因素。
