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[肺和胸膜化脓性疾病患者血浆置换与血液吸附免疫特性的比较研究]

[Comparative studies of immunologic characteristics in plasmapheresis and hemosorption in patients with purulent diseases of the lungs and pleura].

作者信息

Lukomskiĭ G I, Belokrinitskiĭ D V, Alekseeva M E, Saakian N A, Pavliutenkov M G, Kudriashova N M, Dudkina L N, Rumiantseva E G

出版信息

Grud Serdechnososudistaia Khir. 1992(5-6):37-40.

PMID:1389419
Abstract

The article deals with the comparative characteristics of the changes in immunological indices in 40 patients with non-specific purulent diseases of the lungs and pleura when plasmapheresis and hemosorption were included in the complex of therapeutic measures. The changes were found to be hetero-directional in character: a non-specific effect of immunostimulation in hemosorption, and immunodepression, particularly marked in the first 24 hours, in plasmapheresis. The post-aggressive reaction after plasmapheresis is either absent or delayed significantly, which makes it possible to conduct detoxification in extremely grave conditions of the patients without making the mechanisms of the post-aggressive reaction operative, as observed in performance of hemosorption.

摘要

本文探讨了40例肺部和胸膜非特异性化脓性疾病患者在治疗措施中采用血浆置换和血液吸附时免疫指标变化的比较特征。发现这些变化具有异向性:血液吸附具有免疫刺激的非特异性作用,而血浆置换则有免疫抑制作用,在最初24小时尤为明显。血浆置换后的攻击后反应要么不存在,要么显著延迟,这使得在患者病情极其严重的情况下进行解毒成为可能,而不会像血液吸附那样激活攻击后反应机制。

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