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高剂量X射线照射小鼠时出现的异常毛发变白效应。

Anomalous greying effect in mice with higher doses of x-rays.

作者信息

GALBRAITH D B, CHASE H B

出版信息

Science. 1962 Jan 12;135(3498):96-7. doi: 10.1126/science.135.3498.96.

DOI:10.1126/science.135.3498.96
PMID:13896319
Abstract

Exposure of mouse hair follicles to 1200, 1300, and 1400 r of x-rays results in delay of hair growth, precocious melanogenesis, and disruption of melanocyte distribution. The diversity of greying responses obtained with 1100 to 1700 r appears to be due to inactivation of radiosensitive follicles rather than to tissue replacement or to displacement of external sheath melanocytes into the hair bulb.

摘要

将小鼠毛囊暴露于1200、1300和1400伦琴的X射线下,会导致毛发生长延迟、黑素生成早熟以及黑素细胞分布紊乱。用1100至1700伦琴剂量获得的毛发变白反应的多样性,似乎是由于放射敏感毛囊失活,而非组织替代或外鞘黑素细胞向毛球的移位所致。

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引用本文的文献

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Skin Pressing: An Easy and Reliable Method to Induce Acute Hair Greying in Mice and Useful for Studying Canities.皮肤按压:一种诱导小鼠急性毛发变白的简单可靠方法,对研究白发有用。
Exp Dermatol. 2025 Jun;34(6):e70126. doi: 10.1111/exd.70126.
2
Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence.辐照诱导的小鼠毛发变白:一种评估针对氧化应激、DNA 损伤预防和细胞衰老干预措施有效性的实验模型。
Geroscience. 2024 Jun;46(3):3105-3122. doi: 10.1007/s11357-023-01042-7. Epub 2024 Jan 6.