Treston A M, Mulshine J L, Cuttitta F
Biotherapy Section, National Cancer Institute, Bethesda, Md 20895.
J Natl Cancer Inst Monogr. 1992(13):169-75.
Control of the biology of individual cells, organs, and organisms is achieved through an interplay of a host of specific interactions, many involving peptide hormones as modulators or effectors. In tumor cells these processes may result in uncontrolled growth as a consequence of autocrine and/or paracrine growth effects. Most peptide hormones are bioactive only after processing of the precursor prohormone by posttranslational processing enzymes. The enzymes involved with the production of bioactive peptides, in particular those associated with peptide alpha-amidation, provide potential targets for disruption of posttranslational processing mechanisms as a means of regulation of the progression of tumor cells. This information provides a rational basis for consideration of inhibition of autocrine neuropeptide synthesis as a strategy for chemointervention.
对单个细胞、器官和生物体生物学特性的控制是通过一系列特定相互作用的相互影响来实现的，其中许多相互作用涉及肽类激素作为调节剂或效应器。在肿瘤细胞中，这些过程可能由于自分泌和/或旁分泌生长效应而导致不受控制的生长。大多数肽类激素只有在翻译后加工酶对前体激素原进行加工后才具有生物活性。参与生物活性肽产生的酶，特别是那些与肽α-酰胺化相关的酶，为破坏翻译后加工机制提供了潜在靶点，以此作为调节肿瘤细胞进展的一种手段。这一信息为将抑制自分泌神经肽合成作为化学干预策略的考虑提供了合理依据。
