GARROD L P, WATERWORTH P M
J Clin Pathol. 1962 Jul;15(4):328-38. doi: 10.1136/jcp.15.4.328.
a test in liquid medium with subculture and the cellophane transfer method. It is emphasized that information so obtained is necessary in order to predict the effect of combined treatment, particularly in bacterial endocarditis due to organisms not fully sensitive to penicillin. Eight case histories are given, in all of which such a prediction was fulfilled, one of failure and seven of success from the use of five different combinations. The cellophane transfer method was applied to the study of the nature of combined antibiotic action on multiple strains of several bacterial species. The results were rarely uniform for any given combination and species: the necessity for individual tests as a guide to treatment is thus confirmed.Modifications of the theory of combined action formulated by Jawetz are proposed.
液体培养基传代培养试验和玻璃纸转移法。强调指出，为预测联合治疗的效果，尤其是对青霉素不十分敏感的细菌所致的心内膜炎，获取此类信息是必要的。给出了8个病例史，所有病例均实现了这种预测，其中1例治疗失败，7例使用5种不同联合用药方案成功治愈。玻璃纸转移法被用于研究联合抗生素对几种细菌的多个菌株的作用性质。对于任何给定的联合用药方案和菌种，结果很少是一致的：因此证实了进行个体试验作为治疗指导的必要性。文中还提出了对贾韦茨提出的联合作用理论的修正。
