Rocchi G, Sordillo P, Sarrecchia C, Sanguigni V
Cattedra di Clinica delle Malattie Infettive, Università degli Studi Tor Vergata, Roma.
Cardiologia. 1994 Dec;39(12 Suppl 1):267-74.
Antibiotic therapy has improved infective endocarditis prognosis. The observance of general rules to choose the more suitable antibiotic drugs, as regard to their effectiveness, pharmacodynamic peculiarities and use, is mandatory. If the infection is due to antibiotic resistant microorganisms, microbiological analyses to estimate the bactericidal effect of the antibiotics, must be carried out. Resistance to penicillins, oligopeptides and aminoglycosides makes endocarditis produced by Enterococcus spp difficult to treat. The identification of patients at risk for infective endocarditis after surgical and invasive instrumental procedures, allows to introduce antibiotic prophylaxis regimens which can reduce the probability of acquiring the disease.
抗生素治疗改善了感染性心内膜炎的预后。必须遵守一般规则，根据抗生素的有效性、药效学特性和使用方法来选择更合适的抗生素药物。如果感染是由抗生素耐药微生物引起的，则必须进行微生物分析以评估抗生素的杀菌效果。对青霉素、寡肽和氨基糖苷类的耐药性使得肠球菌属引起的心内膜炎难以治疗。识别手术和侵入性器械操作后有感染性心内膜炎风险的患者，有助于引入抗生素预防方案，从而降低患病几率。
