Engle M A, Lang S J, Edelson P
Division of Pediatric Cardiology, New York Hospital, Cornell University Medical Center, NY 10021.
Br Heart J. 1992 May;67(5):409-11. doi: 10.1136/hrt.67.5.409.
An aneurysm of an aortic homograft conduit, used to correct a type I truncus arteriosus anomaly in a four month old infant, developed when the patient was 15. Blood cultures grew Staphylococcus aureus. The aneurysm was detected by magnetic resonance imaging and digital subtraction angiocardiography. An emergency open heart operation, guided by these investigations, was performed to remove the original homograft and replace it with another valved aortic homograft. Postoperative antibiotic treatment had to be stopped when profound neutropenia developed. This responded to treatment with recombinant human granulocyte colony stimulating factor. Three years later she was symptom free and did not require medication. Chest x rays and echocardiograms showed a normally functioning heart and conduit valve.
一名4个月大婴儿曾使用主动脉同种异体移植管道纠正I型共同动脉干畸形，在其15岁时该移植管道出现动脉瘤。血培养结果为金黄色葡萄球菌生长。通过磁共振成像和数字减影血管造影术检测到了动脉瘤。在这些检查的引导下，进行了急诊心脏直视手术，移除原来的同种异体移植物，并用另一个带瓣主动脉同种异体移植物进行替换。术后抗生素治疗因出现严重中性粒细胞减少而不得不停止。这一情况经重组人粒细胞集落刺激因子治疗后得到缓解。三年后，她没有症状，也不需要药物治疗。胸部X光片和超声心动图显示心脏和管道瓣膜功能正常。
