Julía V, Albert A, Morales L, Miró D, Bombi J, Sancho A
Servicio de Cirugía Pediátrica y Anatomía Patológica, Universidad de Barcelona.
Cir Pediatr. 1992 Jul;5(3):117-21.
Recent clinical experience on open prenatal surgery in human beings, although scarce, suggests that skin wound healing in the fetus differs from that in adult life. This fact is supported by several experimental studies. Three types of skin wounds have been practiced in a group of thirty 23rd-gestational-day rabbit fetuses: sutured incision, non-sutured incision, and electrocautery burn. Seven days later, the resulting scars were assessed by mechanical and hystological studies. The results obtained were compared with those seen in 30 newborn rabbits and 30 adult rabbits in which the same wounds were carried out. In the fetuses, rupture tension of the sutured wound was 20% of that of the normal skin. A similar relationship was found in the group of adult rabbits. The sutured wounds in the fetuses showed a better macroscopic repair than in older rabbits. However, the non-sutured wounds and burns did not heal in the fetuses, on the contrary, their opening increased from the time of the lesion. These results seem to suggest that wound repair in the fetus is more like a remodeling process than in older ages.
近期关于人类开放性产前手术的临床经验虽少，但表明胎儿的皮肤伤口愈合与成年期不同。这一事实得到了多项实验研究的支持。在一组30只妊娠第23天的兔胎儿身上制造了三种类型的皮肤伤口：缝合切口、非缝合切口和电灼烧伤。七天后，通过力学和组织学研究评估产生的疤痕。将获得的结果与30只新生兔和30只成年兔身上制造相同伤口后的结果进行比较。在胎儿中，缝合伤口的破裂张力为正常皮肤的20%。在成年兔组中也发现了类似的关系。胎儿的缝合伤口比成年兔显示出更好的宏观修复。然而，非缝合伤口和烧伤在胎儿中并未愈合，相反，从损伤时起其开口就增大了。这些结果似乎表明，胎儿的伤口修复更像是一个重塑过程，而非成年期。
