Preiss G, Brunner P, Tulusan A H
Virchows Arch A Pathol Anat Histol. 1977 Feb 18;373(1):55-65. doi: 10.1007/BF00432468.
Artificial silicone-embolism in rabbits was produced by injection of Baysilon-antifoam into the ear vein. Electron microscopic and histochemical observations of the lung were made, concerning the toxicity and elimination of the embolic material. At 13 months after injection the embolic silicone was not significantly reduced in amount. The rabbit lung is unable to eliminate chemically inert silicone by enzymatic degestion. We noted serious defects of endothelial cells and pneumocytes, destruction of capillaries and local atelectases. These defects are preponderantly mechanical in origin, but may be caused by lack of substrate or energy in cells deprived of their blood supply. Atelectases are interpreted as a result of break-down in surfactant-synthesis.
通过将贝西龙消泡剂注入兔耳静脉来制造兔人工硅栓塞。对肺进行了电子显微镜和组织化学观察，以研究栓塞物质的毒性和清除情况。注射后13个月，栓塞的硅量没有明显减少。兔肺无法通过酶消化清除化学惰性的硅。我们注意到内皮细胞和肺细胞存在严重缺陷、毛细血管破坏以及局部肺不张。这些缺陷主要源于机械因素，但也可能是由于供血被剥夺的细胞缺乏底物或能量所致。肺不张被解释为表面活性剂合成中断的结果。
