PhXA34——一种前列腺素F2α类似物。对高眼压症患者眼压的影响。
PhXA34--a prostaglandin F2 alpha analogue. Effect on intraocular pressure in patients with ocular hypertension.
作者信息
Villumsen J, Alm A
机构信息
Department of Ophthalmology, University of Umeå, Sweden.
出版信息
Br J Ophthalmol. 1992 Apr;76(4):214-7. doi: 10.1136/bjo.76.4.214.
Abstract
PhXA34, a prostaglandin analogue, was given topically to 40 patients with untreated ocular hypertension in a double masked randomised study. One single dose of 0.3, 1, 3, 10 micrograms, or placebo (vehicle) was given to one eye of each patient. A dose related IOP reduction ranging from 11 to 35% was observed with a maximal effect with 3 and 10 micrograms PhXA34. No hyperaemia was seen except after 10 micrograms PhXA34, where a mild to moderate hyperaemia was seen from 8 hours with a duration of up to 24 hours. Mild foreign body sensation in the PhXA34-treated eye was noted by three patients. No cells or flare were seen.
摘要
在一项双盲随机研究中，对40例未经治疗的高眼压患者局部给予前列腺素类似物PhXA34。给每位患者的一只眼睛单次给予0.3、1、3、10微克剂量或安慰剂（赋形剂）。观察到眼压降低与剂量相关，范围为11%至35%，3微克和10微克PhXA34产生最大效果。除10微克PhXA34后出现轻度至中度充血（从8小时开始，持续长达24小时）外，未观察到充血现象。三名患者注意到接受PhXA34治疗的眼睛有轻微异物感。未观察到细胞或闪光。
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