Redondo C, Martínez-Ros C, Galera C
Hospital Universitario Virgen de la Arrixaca, Murcia.
Enferm Infecc Microbiol Clin. 1992 Jun-Jul;10(6):323-7.
To analyze the epidemiologic and clinical features, the survival as well as length of stay of the first 40 AIDS cases seen at the internal Medicine Department of the Virgen de la Arrixaca Hospital (Murcia, Spain).
Prospective study from September 1988 through July 1991. AIDS criteria used were the CDC (1987) ones. The survival analysis was performed using the Kaplan-Meier method.
Thirty-four patients were male (85%) and six female (15%), with a mean age of 39 years. Eighteen (45%) were homo or bisexual, 11 drug addicts (27.5%), 8 (20%) had sexual contacts with prostitutes and/or drug addicts. Two patients were recipients of blood products and in one case no risk could be determined. Opportunistic infections were the first AIDS criteria in 75% of cases. Among the most frequent are P. carinii pneumonia (17.5%), CNS toxoplasmosis (15%) and cryptosporidiosis (12.5%). In 20% of cases a Kaposi's sarcoma developed. The probability of survival after three months was 91% +/- 9.6, at 7 months 79.5% +/- 15.0 and at 15 months 72.5 +/- 18. Overall, 90% of patients had at least one hospital admission, and 27.7% were hospitalized for 50% of more of their survival time.
We recorded an increased number of AIDS cases since 1988, being most of them homo-bisexual male patients, with opportunistic infections as first manifestation. We noticed also high proportion of cases of heterosexual transmission.
分析在阿利克斯卡圣母医院（西班牙穆尔西亚）内科就诊的首批40例艾滋病患者的流行病学和临床特征、生存率以及住院时间。
1988年9月至1991年7月的前瞻性研究。采用的艾滋病诊断标准是美国疾病控制与预防中心（1987年）的标准。使用Kaplan-Meier方法进行生存分析。
34例患者为男性（85%），6例为女性（15%），平均年龄39岁。18例（45%）为同性恋或双性恋，11例吸毒者（27.5%），8例（20%）与妓女和/或吸毒者有性接触。2例患者接受过血液制品，1例无法确定危险因素。机会性感染是75%病例的首个艾滋病诊断标准。最常见的有卡氏肺孢子虫肺炎（17.5%）、中枢神经系统弓形虫病（15%）和隐孢子虫病（12.5%）。20%的病例发生了卡波西肉瘤。三个月后的生存率为91%±9.6，七个月时为79.5%±15.0，十五个月时为72.5±18。总体而言，90%的患者至少住院一次，27.7%的患者住院时间占其生存时间的50%或更多。
自1988年以来我们记录的艾滋病病例有所增加，其中大多数是同性恋-双性恋男性患者，首发表现为机会性感染。我们还注意到异性传播病例的比例很高。
