Vergara de Campos A, Pérez Moreno J M, Bascuñana Quirell A, Torres Tortosa M, Pérez Jiménez F J, Pérez Cortés S, Castillo Palma M J, Pérez Pérez M, Lorente Campos J
Hospital Universitario de Puerto Real.
Med Clin (Barc). 1991 Oct 5;97(11):404-9.
The epidemiological characteristics, clinical manifestations and survival were analyzed in 269 patients with acquired immunodeficiency syndrome (AIDS) diagnosed in the province of Cadiz up to June 1970.
A multicenter protocol study including the 7 hospitals attending practically all of the population of the area of Cadiz was carried out. The diagnosis of AIDS was performed according to the 1987 CDC criteria. The Kaplan and Meier actuarial method was used for the survival study.
The prevalence was of 10 cases in 1986, 37 in 1987, 61 in 1988, 121 in 1989 and 40 during the first 5 months of 1990. Males dominated (84%) and mean age was of 28.6 years. The predominant risk factor was parenteral drug abuse (84%) with signs of social unacceptance (unemployment 70% and with prison records 68%). Thirty eight percent of the patients were no longer drug addicts at the time of diagnosis. The number of cases of women who acquired the disease through heterosexual transmission has increased over the last 2 years (13 cases). Opportunistic infections made up 93% of the diagnostic criteria with esophageal candidiasis (EC) (45%) and extrapulmonary tuberculosis (ET) (34%) being the most frequent. The probability of survival was 14% at 35 months. When ET was the exclusive diagnostic criteria, survival was higher (30% vs 9%) and the mean of T4 lymphocytes in this group was higher (228 vs 154), all being statistically significant.
AIDS is a serious, progressive problem of the Public Health Department in the province of Cadiz and predominantly affects parenteral drug addicts with a percentage higher than other Spanish series in socially unaccepted people. The increase in the cases of women with AIDS from heterosexual transmission is worrisome. EC and ET are the most verified diagnostic criteria. The prognosis of AIDS remains bad at short term, with survival being greater in those patients with ET as the exclusive criteria due to lesser cellular immunodeficiency.
对截至1970年6月在加的斯省确诊的269例获得性免疫缺陷综合征（艾滋病）患者的流行病学特征、临床表现及生存情况进行了分析。
开展了一项多中心方案研究，涵盖了为加的斯地区几乎所有人口提供服务的7家医院。艾滋病诊断依据1987年美国疾病控制与预防中心（CDC）标准进行。生存研究采用Kaplan-Meier精算方法。
1986年患病率为10例，1987年为37例，1988年为61例，1989年为121例，1990年头5个月为40例。男性占主导（84%），平均年龄为28.6岁。主要危险因素是静脉注射吸毒（84%），伴有社会不接受迹象（失业率70%，有入狱记录68%）。38%的患者在诊断时已不再吸毒。过去两年中，通过异性传播感染该病的女性病例数有所增加（13例）。机会性感染占诊断标准的93%，其中食管念珠菌病（EC）（45%）和肺外结核（ET）（34%）最为常见。35个月时的生存概率为14%。当ET是唯一诊断标准时，生存率更高（30%对9%），且该组T4淋巴细胞均值更高（228对154），所有这些均具有统计学意义。
艾滋病是加的斯省公共卫生部门面临的一个严重、渐进性问题，主要影响静脉注射吸毒者，在社会不被接受人群中的比例高于西班牙其他系列报道。艾滋病女性通过异性传播病例数的增加令人担忧。EC和ET是最常见的诊断标准。艾滋病短期预后仍然很差，以ET作为唯一标准的患者由于细胞免疫缺陷较轻，生存率更高。
