LEES P, LOCKETT M F
Br J Pharmacol Chemother. 1963 Feb;20(1):135-8. doi: 10.1111/j.1476-5381.1963.tb01304.x.
Dichloroisoprenaline (1 mg), injected intramuscularly into the rat, retarded the elimination of water and retained sodium, depressing both glomerular filtration rate and renal blood flow. A dose of 4 mg had a similar but more intense action. These actions of dichloroisoprenaline resembled those of 2 or 4 mug of (+/-)-isoprenaline given subcutaneously. Dichloroisoprenaline and (+/-)-isoprenaline summed in salt retaining effect but competed in renal vascular action. 2-Isopropylamino-1-naphth-2'-ylethanol hydrochloride (nethalide, 1 mg intramuscularly) was without action during water diuresis. A dose of 4 mg inhibited solely the excretion of water. Nethalide (1 mg) completely antagonized the antidiuretic and vascular actions of 2 mug of (+/-)-isoprenaline; antagonism of the salt retention caused by (+/-)-isoprenaline was less complete. A dose of 4 mg of nethalide antagonized both the salt retaining and the vascular actions of 4 mug of (+/-)-isoprenaline.
将二氯异丙肾上腺素（1毫克）肌肉注射到大鼠体内，会延缓水分的排出并潴留钠，降低肾小球滤过率和肾血流量。4毫克的剂量有类似但更强烈的作用。二氯异丙肾上腺素的这些作用类似于皮下注射2或4微克（±）-异丙肾上腺素的作用。二氯异丙肾上腺素和（±）-异丙肾上腺素在潴留盐分的作用上相加，但在肾血管作用上相互竞争。2-异丙氨基-1-萘-2'-基乙醇盐酸盐（奈他利定，肌肉注射1毫克）在水利尿期间无作用。4毫克的剂量仅抑制水分的排泄。奈他利定（1毫克）完全拮抗2微克（±）-异丙肾上腺素的抗利尿和血管作用；对（±）-异丙肾上腺素引起的盐分潴留的拮抗作用不太完全。4毫克的奈他利定剂量拮抗4微克（±）-异丙肾上腺素的盐分潴留和血管作用。
