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1
Microbiological degradation of tetracyclines.四环素的微生物降解
J Bacteriol. 1962 Oct;84(4):797-802. doi: 10.1128/jb.84.4.797-802.1962.
2
[In vitro sensitivity of various pathogenic organisms to the 4 tetracyclines demethylchlortetracycline, chlortetracycline, oxytetracycline and tetracycline].[多种致病生物体对去甲金霉素、金霉素、土霉素和四环素这4种四环素的体外敏感性]
Z Mikrosk Anat Forsch. 1960;146:544-7.
3
[ON THE TETRACYCLINES].[关于四环素类药物]
Harefuah. 1964 Mar 15;66:198-9.
4
[THE TETRACYCLINES. I].[四环素类药物。I]
Pharm Weekbl. 1964 Jan 17;99:49-61.
5
DIFFERENCES AMONG TETRACYCLINES WITH RESPECT TO THE STAINING OF TEETH.
J Pediatr. 1965 Sep;67:459-62. doi: 10.1016/s0022-3476(65)80407-3.
6
ANTIBIOTIC THERAPY OF EXPERIMENTAL LEPTOSPIRAL INFECTION IN CHICK EMBRYOS. II. COMPARISON OF THE ACTION OF DEMETHYLCHLORTETRACYCLINE AND THREE OTHER TETRACYCLINES WITH AND WITHOUT ASCORBIC ACID ON LEPTOSPIRA ICTEROHAEMORRHAGIAE.
J Pharm Sci. 1964 May;53:524-8. doi: 10.1002/jps.2600530514.
7
THE EFFECTS OF ADMINISTERING TETRACYCLINES TO YOUNG DOGS WITH PARTICULAR REFERENCE TO LOCALIZATION OF THE DRUGS IN THE TEETH.给幼犬使用四环素的效果，特别提及药物在牙齿中的沉积情况。
Arch Oral Biol. 1963 Nov-Dec;8:715-28. doi: 10.1016/0003-9969(63)90003-7.
8
TOXIC EFFECTS OF THE TETRACYCLINES.
Bull Sloane Hosp Women Columbia Presbyt Med. 1964;10:35-41.
9
[INVESTIGATIONS ON THE QUESTION OF CROSS RESISTANCE OF TETRACYCLINE, OXYTETRACYCLINE, CHLORTETRACYCLINE AND DEMETHYLCHLORTETRACYCLINE TO 40 STRAINS OF STAPHYLOCOCCI].
Chemotherapia (Basel). 1964;64:30-40.
10
[Paper chromatography of tetracyclines].[四环素的纸色谱法]
J Chromatogr. 1963 May;11:62-5. doi: 10.1016/s0021-9673(01)80869-4.

本文引用的文献

1
Bacterial dissimilation of streptomycin.链霉素的细菌异化作用
J Bacteriol. 1961 Oct;82(4):505-10. doi: 10.1128/jb.82.4.505-510.1961.
2
6-Aminopenicillanic acid. VI. Formation of 6-aminopenicillanic acid from penicillin by enzymic hydrolysis.6-氨基青霉烷酸。VI. 通过酶促水解由青霉素形成6-氨基青霉烷酸。
Proc R Soc Lond B Biol Sci. 1961 Aug 15;154:522-31. doi: 10.1098/rspb.1961.0050.
3
Studies on binding of tetracyclines by dog and human plasma.狗和人血浆对四环素结合情况的研究。
Proc Soc Exp Biol Med. 1960 Nov;105:430-3. doi: 10.3181/00379727-105-26130.
4
Metabolism of tetracycline in the rat and the dog.四环素在大鼠和犬体内的代谢。
J Pharmacol Exp Ther. 1960 Oct;130:144-9.
5
Biosynthesis of tetracycline by 5-hydroxy-tetracycline-producing cultures of Streptomyces rimosus.龟裂链霉菌5-羟基四环素生产培养物合成四环素。
J Bacteriol. 1960 Sep;80(3):419-20. doi: 10.1128/jb.80.3.419-420.1960.
6
Selective localization of tetracycline in mitochondria of living cells.四环素在活细胞线粒体中的选择性定位。
Science. 1961 Jan 20;133(3447):196-7. doi: 10.1126/science.133.3447.196.
7
Compatibility of zinc cation with demethyl-chlortetracycline hydrochloride.锌阳离子与盐酸脱甲基金霉素的相容性。
Antibiot Chemother (Northfield). 1961 Aug;11:498-500.
8
Destruction of mitomycin by Streptomyces casepitosus mycelia.酪黄链霉菌菌丝体对丝裂霉素的破坏作用。
Arch Biochem Biophys. 1961 May;93:283-5. doi: 10.1016/0003-9861(61)90263-6.
9
Chloramphenicol, a simultaneous carbon and nitrogen source for a Streptomyces sp. from Egyptain soil.氯霉素，一种来自埃及土壤的链霉菌属菌株的碳氮同步源。
Nature. 1961 Mar 4;189:775-6. doi: 10.1038/189775a0.
10
Decomposition of actinomycin by a soil organism.一种土壤微生物对放线菌素的分解作用。
Science. 1957 Aug 30;126(3270):402-3. doi: 10.1126/science.126.3270.402.

四环素的微生物降解

Microbiological degradation of tetracyclines.

作者信息

MEYERS E, SMITH D A

出版信息

J Bacteriol. 1962 Oct;84(4):797-802. doi: 10.1128/jb.84.4.797-802.1962.

DOI:10.1128/jb.84.4.797-802.1962
PMID:13935339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC277961/
Abstract

Meyers, Edward (Squibb Institute for Medical Research, New Brunswick, N.J.) and Dorothy A. Smith. Microbiological degradation of tetracyclines. J. Bacteriol. 84:797-802. 1962-The degradation of tetracyclines by an ascomycete, Xylaria digitata, was demonstrated. Washedcell suspensions were capable of degrading tetracycline, 5-hydroxytetracycline, 7-chlortetracycline, 7-chlor-6-demethyltetracycline, 2-acetyl-2-decarboxamido-5-hydroxytetracycline, and 12-alpha-deoxytetracycline. The influence of environmental conditions upon the degradation of tetracycline was investigated. A nonantibacterial, nonfluorescent product was located from the degradation of (14)C 5-hydroxytetracycline. Evidence indicated that neither the A nor D ring of 5-hydroxytetracycline is attacked. Acetone powders, lyophilized powders, and cell-free extracts exhibited a relatively limited substrate specificity compared to the washed cells.

摘要

迈尔斯，爱德华（施贵宝医学研究所，新泽西州新不伦瑞克）和多萝西·A·史密斯。四环素的微生物降解。《细菌学杂志》84:797 - 802。1962年——证明了一种子囊菌，指状炭角菌，能降解四环素。洗涤过的细胞悬浮液能够降解四环素、5 - 羟基四环素、7 - 氯四环素、7 - 氯 - 6 - 去甲基四环素、2 - 乙酰 - 2 - 脱羧酰胺基 - 5 - 羟基四环素和12 - α - 脱氧四环素。研究了环境条件对四环素降解的影响。从（14）C 5 - 羟基四环素的降解产物中鉴定出一种无抗菌活性、无荧光的产物。证据表明5 - 羟基四环素的A环和D环均未受到攻击。与洗涤过的细胞相比，丙酮粉、冻干粉和无细胞提取物表现出相对有限的底物特异性。