四环素的微生物降解

Microbiological degradation of tetracyclines.

作者信息

MEYERS E, SMITH D A

出版信息

J Bacteriol. 1962 Oct;84(4):797-802. doi: 10.1128/jb.84.4.797-802.1962.

DOI:10.1128/jb.84.4.797-802.1962

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC277961/

Abstract

Meyers, Edward (Squibb Institute for Medical Research, New Brunswick, N.J.) and Dorothy A. Smith. Microbiological degradation of tetracyclines. J. Bacteriol. 84:797-802. 1962-The degradation of tetracyclines by an ascomycete, Xylaria digitata, was demonstrated. Washedcell suspensions were capable of degrading tetracycline, 5-hydroxytetracycline, 7-chlortetracycline, 7-chlor-6-demethyltetracycline, 2-acetyl-2-decarboxamido-5-hydroxytetracycline, and 12-alpha-deoxytetracycline. The influence of environmental conditions upon the degradation of tetracycline was investigated. A nonantibacterial, nonfluorescent product was located from the degradation of (14)C 5-hydroxytetracycline. Evidence indicated that neither the A nor D ring of 5-hydroxytetracycline is attacked. Acetone powders, lyophilized powders, and cell-free extracts exhibited a relatively limited substrate specificity compared to the washed cells.

摘要

迈尔斯，爱德华（施贵宝医学研究所，新泽西州新不伦瑞克）和多萝西·A·史密斯。四环素的微生物降解。《细菌学杂志》84:797 - 802。1962年——证明了一种子囊菌，指状炭角菌，能降解四环素。洗涤过的细胞悬浮液能够降解四环素、5 - 羟基四环素、7 - 氯四环素、7 - 氯 - 6 - 去甲基四环素、2 - 乙酰 - 2 - 脱羧酰胺基 - 5 - 羟基四环素和12 - α - 脱氧四环素。研究了环境条件对四环素降解的影响。从（14）C 5 - 羟基四环素的降解产物中鉴定出一种无抗菌活性、无荧光的产物。证据表明5 - 羟基四环素的A环和D环均未受到攻击。与洗涤过的细胞相比，丙酮粉、冻干粉和无细胞提取物表现出相对有限的底物特异性。

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