裴氏着色真菌：脂质组成及对两性霉素B敏感性的测定

Fonsecaea pedrosoi: lipid composition and determination of susceptibility to amphotericin B.

作者信息

Gomes M H, Resende M A

机构信息

Departamento de Microbiologia, Instituto de Ciências Biológicas Universidade Federal de Minas Gerais, Brazil.

出版信息

Can J Microbiol. 1992 Mar;38(3):209-14. doi: 10.1139/m92-035.

DOI:10.1139/m92-035

PMID:1393822

Abstract

Conidia and mycelial cells of Fonsecaea pedrosoi ATCC 46428 were obtained for analyses of lipid composition. Total lipids, phospholipids, sterols, and qualitative sterols and fatty acid composition were determined. A higher lipid content was detected in conidia than in mycelial cells of Fonsecaea pedrosoi, which could not be attributed to total sterols and phospholipids. In both forms of this fungus, ergosterol was the only sterol detected. The minimal inhibitory concentration of amphotericin B was lower for conidia than for mycelium.

摘要

获取佩德罗霉样真菌（Fonsecaea pedrosoi）ATCC 46428的分生孢子和菌丝体细胞用于脂质成分分析。测定了总脂质、磷脂、甾醇、定性甾醇和脂肪酸组成。结果发现，佩德罗霉样真菌的分生孢子中的脂质含量高于菌丝体细胞，这不能归因于总甾醇和磷脂。在该真菌的两种形态中，麦角甾醇是唯一检测到的甾醇。两性霉素B对分生孢子的最低抑菌浓度低于对菌丝体的最低抑菌浓度。