Filous A, Rychnová J, Vavrinec J
Dĕtská ocní klinika FN v Motole, Praha.
Cesk Pediatr. 1992 Aug;47(8):456-9.
In a retrospective investigation the authors give an account of a group of 302 children and adolescents with insulin dependent diabetes (mean age 14.2 years, mean duration of diabetes 6.4 years) whom they examine regularly by chromatoophtalmoscopy and evaluate the findings according to their own extended classification of diabetic retinopathy. In 29% of the patients the finding was positive and in 25% the finding was suspect. The most frequent pathological change were microaneurysms; intraretinal microvascular abnormalities (IRMA) were detected in 13 patients. The trend towards proliferative changes is apparent in some patients surprisingly soon. The authors emphasize the sensitivity of the method which along with the extended classification of retinopathy makes its monitoring possible. The authors discuss the value of fluorescent angiography in the initial stages of retinal damage. They provide evidence of a statistically significant relationship of diabetic retinopathy and the duration of diabetes (p < 0.001) and age (p < 0.001).
在一项回顾性调查中,作者报告了一组302例胰岛素依赖型糖尿病儿童和青少年(平均年龄14.2岁,平均糖尿病病程6.4年),他们通过彩色眼底镜对这些患者进行定期检查,并根据自己扩展的糖尿病视网膜病变分类对检查结果进行评估。29%的患者检查结果为阳性,25%的患者检查结果可疑。最常见的病理变化是微动脉瘤;在13例患者中检测到视网膜内微血管异常(IRMA)。令人惊讶的是,在一些患者中,增殖性变化的趋势很快就显现出来。作者强调了该方法的敏感性,连同视网膜病变的扩展分类,使其监测成为可能。作者讨论了荧光血管造影在视网膜损伤初始阶段的价值。他们提供证据表明糖尿病视网膜病变与糖尿病病程(p < 0.001)和年龄(p < 0.001)之间存在统计学上的显著关系。