右旋糖酐铁预防铟中毒
Prevention of indium intoxication by ferric dextran.
作者信息
GABBIANI G, SELYE H, TUCHWEBER B
出版信息
Br J Pharmacol Chemother. 1962 Dec;19(3):508-12. doi: 10.1111/j.1476-5381.1962.tb01456.x.
Abstract
Experiments on the rat indicate that intravenous administration of indium chloride produces severe hepatic necroses with fatal icterus within a few days. These actions can be prevented by the prophylactic administration of ferric dextran. This protective effect of the iron compound must be largely specific since it could not be duplicated by pretreatment with any of a large series of other agents. The possible mechanism of the protective effect is briefly discussed.
摘要
对大鼠的实验表明，静脉注射氯化铟会在数天内导致严重的肝坏死并伴有致命性黄疸。这些作用可通过预防性给予右旋糖酐铁来预防。铁化合物的这种保护作用一定在很大程度上具有特异性，因为用一大系列其他药物进行预处理无法复制这种作用。文中简要讨论了保护作用的可能机制。
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