Hiraoka A, Miura I, Satô M, Tominaga I, Hattori M
Kyorin University School of Health Sciences, Tokyo, Japan.
Chem Pharm Bull (Tokyo). 1992 Jun;40(6):1629-30. doi: 10.1248/cpb.40.1629.
Effects of four anti-epileptic drugs (AED; phenobarbital, phenytoin, carbamazepine and sodium valproate) on the L-tryptophan binding to human serum albumin were studied. Among these drugs examined, only sodium valproate inhibited the binding even within the concentrations of its therapeutic range, and the Klotz plotting analysis revealed that the inhibition was competitive. The results of examinations with sera from epileptic patients medicated with these AED and drug-free normal controls also suggested that the protein binding ratios of L-tryptophan were decreased in the blood plasma of some patients with the high valproate concentrations and the low albumin contents.
研究了四种抗癫痫药物（AED；苯巴比妥、苯妥英、卡马西平和丙戊酸钠）对L-色氨酸与人血清白蛋白结合的影响。在所检测的这些药物中，只有丙戊酸钠即使在其治疗浓度范围内也能抑制这种结合，并且Klotz作图分析表明这种抑制是竞争性的。对服用这些抗癫痫药物的癫痫患者血清以及未服药的正常对照血清的检测结果也表明，在一些丙戊酸浓度高且白蛋白含量低的患者血浆中，L-色氨酸的蛋白结合率降低。
