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遗传密码字典的起源与生物个体性

Origin and biologic individuality of the genetic dictionary.

作者信息

GIACOMONI D, SPIEGELMAN S

出版信息

Science. 1962 Dec 21;138(3547):1328-31. doi: 10.1126/science.138.3547.1328.

DOI:10.1126/science.138.3547.1328
PMID:13947582
Abstract

Deoxyribonucleic acid contains sequences complementary to homologous amino-acid transfer ribonucleic acid molecules which serve as the translating device between polyribonucleotides and proteins. This implies that the RNA molecules have their primary origin in DNA. From the amount of DNA participating, one would infer that more than 20 complementary sequences exist per genome, a conclusion consistent with a degenerate code. The fact that complex formation occurs most readily with homologous RNA suggests that, while the language remains universal, each dictionary is uniquely identifiable with its own genome.

摘要

脱氧核糖核酸含有与同源氨基酸转移核糖核酸分子互补的序列,这些分子充当多核糖核苷酸和蛋白质之间的翻译装置。这意味着RNA分子最初起源于DNA。从参与的DNA量来看,人们可以推断每个基因组中存在20多个互补序列,这一结论与简并密码一致。与同源RNA最容易形成复合物这一事实表明,虽然语言仍然通用,但每个“词典”都可以通过其自身的基因组唯一识别。

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Proc Natl Acad Sci U S A. 1964 May;51(5):818-26. doi: 10.1073/pnas.51.5.818.
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