Shinohara M, Motohashi N, Fukuzawa H, Akiyama Y, Kariya T
Department of Neuropsychiatry, Yamanashi Medical College.
Rinsho Shinkeigaku. 1992 Apr;32(4):444-6.
A 30-year-old female received a head injury at the age of 22 years. Subsequently neurological and psychiatric symptoms, such as personality change, urinary incontinence, dementia and gait disturbance developed. On admission, her cognitive function was severely impaired. Brain CT disclosed cerebral atrophy, dilatation of the lateral ventricle and calcification of the basal ganglia. Pathologically membranous structures were recognized in bone marrow. On the basis of these clinical findings, a diagnosis of Nasu-Hakola's disease was made. In this case, a T2-weighted MRI finding of reduced signal intensity in the thalamus and putamen was characteristic. This finding may be related to intracranial calcification.
一名30岁女性在22岁时头部受伤。随后出现了神经和精神症状，如人格改变、尿失禁、痴呆和步态障碍。入院时，她的认知功能严重受损。脑部CT显示脑萎缩、侧脑室扩张和基底节钙化。病理检查发现骨髓中有膜状结构。基于这些临床发现，诊断为纳苏-哈科拉病。在该病例中，T2加权磁共振成像显示丘脑和壳核信号强度降低是其特征性表现。这一发现可能与颅内钙化有关。
