Alessandri C, Basili S, Peverini F, Barsi R, Paradiso M, Coppotelli L, Violi F, Cordova C
Fondazione Andrea Cesalpino, Istituto di I Clinica Medica dell'Università La Sapienza di Roma.
Clin Ter. 1992 Aug;141(8):109-14.
Forty-three male patients with myocardial infarction, severe angiographic coronary lesions, high or normal low density lipoprotein (LDL) cholesterol serum levels, and without other risk factors for coronary heart disease were selected. In all patients high density lipoprotein (HDL) cholesterol and HDL-cholesterol/total cholesterol ratio were significantly lower than in the control group; in particular, the ratio was below 0.240 which was the median value of normal subjects. Six patients with total cholesterol and LDL-cholesterol below 5.16 and 3.35 mmol/l respectively, had low serum levels of HDL-cholesterol; in 4 of them the value of this risk factor was below 0.9 mmol/l; 2 of 6 patients had a lipoprotein (a) serum concentration above 0.3 g/l but not a premature myocardial infarction or a clinical history of coronary heart disease. Our data confirm that HDL-cholesterol/total cholesterol ratio could be a better marker of coronary heart disease than HDL-cholesterol, total cholesterol or LDL-cholesterol and suggest the importance to check HDL-cholesterol serum levels also in subjects without risk factors for atherosclerotic disease.
选取了43例男性心肌梗死患者，这些患者冠状动脉造影显示有严重病变，低密度脂蛋白（LDL）胆固醇血清水平高或正常，且无其他冠心病危险因素。所有患者的高密度脂蛋白（HDL）胆固醇及HDL胆固醇/总胆固醇比值均显著低于对照组；尤其是该比值低于0.240，而0.240是正常受试者的中位数。6例总胆固醇和LDL胆固醇分别低于5.16和3.35 mmol/l的患者，其HDL胆固醇血清水平较低；其中4例该危险因素的值低于0.9 mmol/l；6例患者中有2例脂蛋白（a）血清浓度高于0.3 g/l，但无早发性心肌梗死或冠心病临床病史。我们的数据证实，HDL胆固醇/总胆固醇比值可能是比HDL胆固醇、总胆固醇或LDL胆固醇更好的冠心病标志物，并提示在无动脉粥样硬化疾病危险因素的受试者中也有必要检测HDL胆固醇血清水平。
