Gillis S, Connors G, Potts P, Hunse C, Richardson B
Department of Obstetrics and Gynaecology, Lawson Research Institute, St. Joseph's Health Care Centre, London, Ontario, Canada.
Early Hum Dev. 1992 Aug;30(1):1-10. doi: 10.1016/0378-3782(92)90081-q.
Twenty-four healthy pregnant women were studied between 36 and 40 weeks gestation to determine the effect of glucose on the Doppler flow velocity waveform in the cerebral and umbilical arteries of the human fetus near term. The Resistance Index (RI), as an index of vascular resistance, was calculated for the anterior cerebral, internal carotid and umbilical arteries during a fasting control period, 45 min and again at 120 min after a 50-g maternal oral glucose drink or an equivalent amount of water. Fetal heart rate (FHR) pattern as determined by FHR variability was monitored as a measure of behavioural state. The RI of both cerebral vessels was significantly lower after the glucose drink, while that of the umbilical artery was little changed subsequent to either of the drinks. However the FHR mean min range, as an index of long term FHR variability was significantly increased when measured 30 to 60 min after the glucose drink and controlling for this change removed the effect of glucose on the RI of the cerebral vessels. We conclude that glucose does have an indirect effect on the cerebral Doppler waveform indices of the human fetus which is mediated through induced changes in behavioural state.
对24名妊娠36至40周的健康孕妇进行了研究，以确定葡萄糖对足月胎儿大脑和脐动脉多普勒血流速度波形的影响。在空腹对照期、饮用50克口服葡萄糖饮品或等量水后45分钟及120分钟时，计算大脑前动脉、颈内动脉和脐动脉的阻力指数（RI），作为血管阻力的指标。通过胎儿心率变异性确定的胎儿心率（FHR）模式作为行为状态的指标进行监测。饮用葡萄糖饮品后，两条脑血管的RI均显著降低，而饮用两种饮品后脐动脉的RI变化不大。然而，饮用葡萄糖饮品后30至60分钟测量时，作为长期FHR变异性指标的FHR平均分钟范围显著增加，控制这一变化后消除了葡萄糖对脑血管RI的影响。我们得出结论，葡萄糖确实对人类胎儿的大脑多普勒波形指数有间接影响，这种影响是通过行为状态的诱导变化介导的。
