Simmonds R J, James A M
Cytobios. 1976;15(60):191-200.
A technique is described for the in vitro study of the interaction of barium sulphate suspensions, used as radiopaques, with rat ileum. The technique, which allows close approximation to the in vivo situation with accurate control of the experimental conditions, was shown to give reproducible results. The thickness of the radiopaque retained at the gut surface was related to the concentration of the suspension, but was not significantly affected by the pH of the suspension. Less viscous suspensions gave better coating of the gut surface. The nature of the stabilizing agent or the surface charge carried by the particles does not affect the adhesion of the particles to the ileal mucus.
本文描述了一种用于体外研究作为造影剂的硫酸钡悬浮液与大鼠回肠相互作用的技术。该技术能够在精确控制实验条件的情况下，非常接近体内情况，且结果具有可重复性。肠道表面保留的造影剂厚度与悬浮液浓度有关，但不受悬浮液pH值的显著影响。粘性较小的悬浮液能更好地覆盖肠道表面。稳定剂的性质或颗粒所带的表面电荷不会影响颗粒与回肠黏液的黏附。
