Maroni M, Bulgheroni C, Cassitto M G, Merluzzi F, Gilioli R, Foa' V
Scand J Work Environ Health. 1977 Mar;3(1):16-22. doi: 10.5271/sjweh.2797.
Twenty-two female subjects working in a factory in which 1,1,1-trichloroethane was the only solvent used were investigated by means of clinical, neurophysiological and psychometric methods so that the neurotoxicity of the solvent could be evaluated. On the basis of the ambient air concentrations of 1,1,1-trichloroethane ranging from 110 to 990 ppm, the workers were divided into three risk groups and compared with a reference group. No significant difference was observed between the exposed and unexposed females with respect to clinical features, maximal motor conduction velocity, conduction velocity of slow fibers, and psychometric data. The most frequent complaints of the workers were of the "neurotic" type with a slightly higher, but not significant, difference in the exposed group. The results obtained favor the absence of a manifest neurotoxic effect of 1,1,1-trichloroethane under the specific work conditions of the investigation; generally unfavorable work conditions seem to have played a prominent role in the genesis of the neurotic complaints. The importance of a global methodological approach in the study of work-related risks, particularly in neurological and psychological surveys, is stressed.
对一家仅使用1,1,1 - 三氯乙烷作为溶剂的工厂里的22名女性工人进行了临床、神经生理学和心理测量学方面的调查，以便评估该溶剂的神经毒性。根据工作环境中1,1,1 - 三氯乙烷的浓度在110至990 ppm之间，将这些工人分为三个风险组，并与一个对照组进行比较。在临床特征、最大运动传导速度、慢纤维传导速度和心理测量数据方面，未观察到暴露组和未暴露组女性之间存在显著差异。工人们最常见的主诉属于“神经症”类型，暴露组的差异略高，但不显著。在该调查的特定工作条件下，所获得的结果表明不存在1,1,1 - 三氯乙烷明显的神经毒性作用；一般不利的工作条件似乎在神经症性主诉的发生中起了重要作用。强调了在研究与工作相关的风险时，尤其是在神经学和心理学调查中，采用全面方法的重要性。
